The House of Da Vinci 3 immerses players in Giacomo's journey as Leonardo da Vinci's partner. Players experience the narrative from a first-person viewpoint, exploring renowned Renaissance sites. Engaging with a series of puzzles, players unlock discovery points sequentially. Solving one puzzle leads to the next, creating a continuous path of challenges. The game allows players to travel through time, expanding the storyline. Characters encountered along the way may become allies or adversaries, and their responses to challenges will significantly impact the journey.

Players can activate time portals in The House of Da Vinci 3 to revisit specific eras. The Oculus Perpetua ability assists in creating these portals. Challenges presented by the game are addressed by altering past events. Upon returning to the present, all narrative details are revitalized. Giacomo interacts with various objects to uncover mysteries within the environment. Complex puzzles are enhanced with exotic devices, testing players' observation and perception skills to identify anomalies within the rooms.

The picturesque landscape of Italy serves as the backdrop for The House of Da Vinci 3's storyline. Majestic castles are interconnected by subterranean tunnels. Players uncover hidden secrets to earn significant rewards. Utilizing press-and-release mechanics, players navigate rescue missions. The adventure spans multiple locations and timelines, enriching players' experiences in overcoming obstacles. Giacomo's story unfolds through a video upon mission completion, blending unique elements throughout the gameplay. Realistic visuals and compelling narrative voiceovers enhance the story's impact.